The theory and application of intravascular microbubbles as an ultra-effective means of transporting oxygen and other gases.

Download Adobe Acrobat Reader DocumentAbstract - Theoretically, volume-stabilized microbubbles may effectively support gas exchange between lungs and tissues. Subcapillary sized bubbles can be generated by i.v. injection of an emulsion of dodecafluoropentane (DDFP). The feasibility of this method for life-sustaining oxygen supply has now been demonstrated in five studies. The efficiency of the microbubbles for O2 transport is underscored by the extremely small doses (0.002-0.014 ml/kg body weight) of DDFP, in the form of a 2% emulsion, which were used in these experimental studies. Dated: 2004