Reversal of Tumor hypoxia following intravenous delivery of nano-droplet DDFP, a novel oxygen-transport agent: fiber-optic oxygen probe measurement and MRI characterization

Download Adobe Acrobat Reader Document DDFPe significantly increases xenograft pO2 for up to 45 minutes via fiber-optic probe measurement. This agent may offer a novel means of transient reversal of tumor hypoxia in concert with chemoradiation. Click here to read the publication.

Dynamic Oxygenation Measurements Using a Phosphorescent Coating Window Chamber Model

Download Adobe Acrobat Reader DocumentA mouse tumor window chamber model was made to measure the amount of oxygen in tumors in mice over time. The mice are injected with NuvOx Pharma's NVX-108, and the level of oxygen in the tumors increases significantly in the next few minutes and remains elevated for the entire 63 minute monitoring period. Dated: 2015

Radiosensitization of Hs-766T Pancreatic Tumor Xenografts in Mice Dosed with…

Download Adobe Acrobat Reader DocumentTumor hypoxia is an important mediator of radiation therapy resistance. We conducted a study to investigate whether an oxygen therapeutic based upon dodecafluoropentane (DDFP) nano-emulsion (NVX-108) could increase tumor pO2 in hypoxic tumors and improve radiation response. Dated: 2014

Radiosensitization of Hypoxic Tumor Cells by Dodecafluoropentane

Download Adobe Acrobat Reader DocumentOne method to make hypoxic, radioresistant cells more radiation sensitive has been to increase the oxygen carrying capacity of normal blood using liquid perfluorochemical emulsions combined with breathing high pO2 gases. We investigated the ability of dodecafluoropentane (DDFP) to sensitize the moderately radiation-resistant Morris 7777 hepatoma based on our previous inability to modify the radiation response of this tumor. Dated: 2002

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

Download Adobe Acrobat Reader DocumentOriginally published in 1953, this seminal work by Gray first described oxygen’s ability to be a radiosensitizer for the treatment of solid tumors. Further work over the following decades has confirmed this observation. Gray later had a unit of measure named after him for his pioneering work – one Gray is defined as the absorption of one joule of radiation energy per kilogram of matter. Click here to read the publication.