Radiosensitization of Hypoxic Tumor Cells by Dodecafluoropentane

Download Adobe Acrobat Reader DocumentOne method to make hypoxic, radioresistant cells more radiation sensitive has been to increase the oxygen carrying capacity of normal blood using liquid perfluorochemical emulsions combined with breathing high pO2 gases. We investigated the ability of dodecafluoropentane (DDFP) to sensitize the moderately radiation-resistant Morris 7777 hepatoma based on our previous inability to modify the radiation response of this tumor. Dated: 2002

The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy

Download Adobe Acrobat Reader DocumentOriginally published in 1953, this seminal work by Gray first described oxygen’s ability to be a radiosensitizer for the treatment of solid tumors. Further work over the following decades has confirmed this observation. Gray later had a unit of measure named after him for his pioneering work – one Gray is defined as the absorption of one joule of radiation energy per kilogram of matter. Click here to read the publication.