DDFPe significantly increases xenograft pO2 for up to 45 minutes via fiber-optic probe measurement. This agent may offer a novel means of transient reversal of tumor hypoxia in concert with chemoradiation. Click here to read the publication.
A mouse tumor window chamber model was made to measure the amount of oxygen in tumors in mice over time. The mice are injected with NuvOx Pharma's NVX-108, and the level of oxygen in the tumors increases significantly in the next few minutes and remains elevated for the entire 63 minute monitoring period. Dated: 2015
One method to make hypoxic, radioresistant cells more radiation sensitive has been to increase the oxygen carrying capacity of normal blood using liquid perfluorochemical emulsions combined with breathing high pO2 gases. We investigated the ability of dodecafluoropentane (DDFP) to sensitize the moderately radiation-resistant Morris 7777 hepatoma based on our previous inability to modify the radiation response of this tumor. Dated: 2002
Originally published in 1953, this seminal work by Gray first described oxygen’s ability to be a radiosensitizer for the treatment of solid tumors. Further work over the following decades has confirmed this observation. Gray later had a unit of measure named after him for his pioneering work – one Gray is defined as the absorption of one joule of radiation energy per kilogram of matter. Click here to read the publication.