DDFPe was injected into rabbits and blood samples were taken over time. A 2-compartment model was the best fit to the DDFP blood concentration-time profiles in each of the animals tested. A rapid distribution phase followed by a longer elimination phase was observed. In this species, the distribution phase half-life was 1.15 ± 0.6 min while the elimination half-life was 13.5 ± 11 min (N=4) Dated: 2015
Previous data collected on 195 New Zealand White male or female rabbits with permanent occlusion of the cerebral arteries with two to three 700-900 micron diameter spheres was further reviewed to determine incidence of mortality in all controls and DDFPe treatment groups. The conclusion is that increasing the number of DDFPe applications was significant in reducing the incidence of premature death in a model of permanent ischemic stroke and extending survival to scheduled sacrifice. This new perfluorocarbon has previously demonstrated decreased stroke volume in the rabbit stroke model and now further indicates its ability to significantly reduce the incidence of death.
Dodecafloropentane emulsion (DDFPe) is not indicated in the treatment of decompression injury. In the setting of rapid decompression from a hyperbaric environment, it is likely that DDFPe's microbubbles act as nuclei for the formation of larger bubbles. DDFPe, because of its quasi-bubble state, is able to transfer far more oxygen than other materials and shows great promise in other indications such as stroke, heart attack, cancer, traumatic brain injury, blood loss, sickle cell crisis, and other conditions. However, it seems that treatment of decompression injury is not appropriate. This research provided a better understanding of the mechanism of action of DDFPe. Dated: 2015
Abstract - Animal studies have repeatedly shown Dodecafluoropentane emulsion (DDFPe) neuroprotection in ischemic strokes in the anterior circulation; however, when a posterior vessel is also occluded, the intricate cerebral dynamics may be altered. Many studies have used standard anterior circulation occlusions as their stroke model, but approximately 20% of ischemic strokes involve the nonstandard posterior circulation. Animals in the non-standard group that were given both anterior and posterior strokes showed no statistically significant change in stroke volume (p=0.82) with treatment, while animals in the standard group showed statistically significant reductions in stroke volume (p=0.018) with treatment. Dated: 2015
Very high doses of DDFP were injected into New Zeland white rabbits. DDFP promptly reaches the brain and concentrations rise in all tissues with multiple doses. Future studies will develop a dosing regimen to optimize a wide range of therapeutic effects in ischemic states and minimize toxicity. Dated: 2014