Blood Pharmacokinetics Of Dodecafluoropentane Following Administration Of Dodecafluoropentane Emulsion To Rabbits

Download Adobe Acrobat Reader DocumentDDFPe was injected into rabbits and blood samples were taken over time. A 2-compartment model was the best fit to the DDFP blood concentration-time profiles in each of the animals tested. A rapid distribution phase followed by a longer elimination phase was observed. In this species, the distribution phase half-life was 1.15 ± 0.6 min while the elimination half-life was 13.5 ± 11 min (N=4) Dated: 2015

Human pharmacokinetics of a perfluorocarbon ultrasound contrast agent evaluated with gas chromatography.

Download Adobe Acrobat Reader DocumentThe purpose of this study was to prospectively study the human pharmacokinetics of an ultrasound (US) contrast agent through its active ingredient, dodecafluoropentane (DDFP). In expired air, DDFP concentration exhibited a biexponential decay. The percentage of recovery was 98 +/- 19% at 2 h. No extraneous peaks were observed, indicating no detectable DDFP metabolites. It was concluded that DDFP pharmacokinetics in blood fitted to an open one-compartment model with a fast elimination half-life. Recovery in expired air was almost complete 2 h after administration. Dated: 2001