This study administered nine dosing regimens of DDFPe into New Zealand White Rabbits, the same species used for the majority of pre-clinical studies in stroke. The study describes DDFP distribution in brain, kidney, liver, spleen, and lung. The total clearance of DDFP was consistent with previous reports showing 98% of DDFP is cleared within 2 h of administration.
DDFPe was injected into New Zealand white rabbits and blood samples were taken over time. A 2-compartment model was the best fit to the DDFP blood concentration-time profiles in each of the animals tested. The drug showed a rapid distribution phase followed by a longer elimination phase. In this species, the distribution phase half-life was 1.15 ± 0.6 min while the elimination half-life was 13.5 ± 11 min.