Tissue Concentration of Dodecafluoropentane (DDFP) Following Repeated IV Administration in the New Zealand White Rabbit

Download Adobe Acrobat Reader DocumentThis study administered nine dosing regimens of DDFPe into New Zealand White Rabbits, the same species used for the majority of pre-clinical studies in stroke. The study describes DDFP distribution in brain, kidney, liver, spleen, and lung. The total clearance of DDFP was consistent with previous reports showing 98% of DDFP is cleared within 2 h of administration.

Blood Pharmacokinetics Of Dodecafluoropentane Following Administration Of Dodecafluoropentane Emulsion To Rabbits

Download Adobe Acrobat Reader DocumentDDFPe was injected into New Zealand white rabbits and blood samples were taken over time. A 2-compartment model was the best fit to the DDFP blood concentration-time profiles in each of the animals tested. The drug showed a rapid distribution phase followed by a longer elimination phase. In this species, the distribution phase half-life was 1.15 ± 0.6 min while the elimination half-life was 13.5 ± 11 min.