Repeated Doses of DDFPe Provide Neuroprotection Up to 24 Hours Following Cerebral Artery Occlusion in Rabbits

Download Adobe Acrobat Reader DocumentAbstract - New Zeland White Rabbits (n=55) received cerebral angiography from a femoral artery approach. Embolic microspheres (diameter=700-900 μm) were injected into the internal carotid artery, permanently occluding the middle cerebral and/or anterior cerebral arteries. Rabbits were randomly assigned to treatment groups and sacrifice times. Intravenous DDFPe begun 1 hour after stroke onset protects the brain from ischemic injury in the rabbit model of permanent embolic stroke. Decreased infarct volumes represent salvaged brain tissue. This effect can be observed for 24 hours with repeated doses. Dated 2013.