Dodecafluoropentane (DDFPe) and Decompression Sickness-Related Mortality in Rats

Download Adobe Acrobat Reader DocumentDodecafloropentane emulsion (DDFPe) is not indicated in the treatment of decompression injury. In the setting of rapid decompression from a hyperbaric environment, it is likely that DDFPe's microbubbles act as nuclei for the formation of larger bubbles. DDFPe, because of its quasi-bubble state, is able to transfer far more oxygen than other materials and shows great promise in other indications such as stroke, heart attack, cancer, traumatic brain injury, blood loss, sickle cell crisis, and other conditions. However, it seems that treatment of decompression injury is not appropriate. This research provided a better understanding of the mechanism of action of DDFPe. Dated: 2015

Cardiovascular drug delivery with ultrasound and microbubbles

Download Adobe Acrobat Reader DocumentMicrobubbles lower the threshold for cavitation of ultrasound and have multiple potential therapeutic application in the cardiovascular system. Dated: 2014

Hypoxia Due to Shunts in Pig Lung Treated with O2 and Fluorocarbon-derived Intravascular Microbubbles

Download Adobe Acrobat Reader DocumentThe results suggest that intravascular administration of a DDFPe and oxygen breathing may be beneficial in severe right-to-left shunting in humans. Dated: 2010

Intravascular Perfluorocarbon Stabilized Microbubbles for Treatment of Hypoxemia Due to an Experimental Pulmonary Shunt

Download Adobe Acrobat Reader DocumentPlease see page 106 of the pdf. Circulatory left to right shunts present an intruiging problem because O2 breathing will not substantially increase the O2 content of the unshunted blood or the total O2 delivery. In this study, pigs airways were blocked using steel beads. The pigs received infusions of DDFPe. Minutes after the infusion, the PaO2 increased in all treated animals. PaCO2 and pH normalized after infusion. The results lasted up to 5 hours. These results suggest that DDFPe infusion in combination with O2 breathing could be a valuable treatment to mitigate hypoxemia in right-to-left circulatory shunts of different etiologies.