Repeated Doses of DDFPe Provide Neuroprotection Up to 24 Hours Following Cerebral Artery Occlusion in Rabbits
Abstract - New Zeland White Rabbits (n=55) received cerebral angiography from a femoral artery approach. Embolic microspheres (diameter=700-900 μm) were injected into the internal carotid artery, permanently occluding the middle cerebral and/or anterior cerebral arteries. Rabbits were randomly assigned to treatment groups and sacrifice times. Intravenous DDFPe begun 1 hour after stroke onset protects the brain from ischemic injury in the rabbit model of permanent embolic stroke. Decreased infarct volumes represent salvaged brain tissue. This effect can be observed for 24 hours with repeated doses. Dated 2013.
Dodecafluoropentane Emulsion (DDFPe) Decreases Stroke Size and Improves Neurological Scores in a Permanent Occlusion Rat Stroke Model.
Abstract - Animal studies have repeatedly shown Dodecafluoropentane emulsion (DDFPe) neuroprotection in ischemic strokes in the anterior circulation; however, when a posterior vessel is also occluded, the intricate cerebral dynamics may be altered. Many studies have used standard anterior circulation occlusions as their stroke model, but approximately 20% of ischemic strokes involve the nonstandard posterior circulation. Animals in the non-standard group that were given both anterior and posterior strokes showed no statistically significant change in stroke volume (p=0.82) with treatment, while animals in the standard group showed statistically significant reductions in stroke volume (p=0.018) with treatment. Dated: 2015
Dodecafluoropentane emulsion delays and reduces MRI markers of infarction in a rat stroke model: a preliminary report.
Multiple Applications of Dodecafluropentane emulsion (DDFPe) Prevents Death in a Rabbit Stroke Model of Permanent Ischemia
Abstract - Previous data collected on 195 New Zealand White male or female rabbits with permanent occlusion of the cerebral arteries with two to three 700-900 micron diameter spheres was further reviewed to determine incidence of mortality in all controls and DDFPe treatment groups. The conclusion is that increasing the number of DDFPe applications was significant in reducing the incidence of premature death in a model of permanent ischemic stroke and extending survival to scheduled sacrifice. This new perfluorocarbon has previously demonstrated decreased stroke volume in the rabbit stroke model and now further indicates its ability to significantly reduce the incidence of death. Dated: 2015
DDFPe nanodroplets are exceptional oxygen transporters and can protect ischemic brain in stroke models 24 h without reperfusion. Current stroke therapy usually fails to reach patients because of delays following stroke onset. We tested using DDFPe to extend the time window for tissue plasminogen activator (tPA). Longer treatment windows will allow more patients more complete stroke recovery. We test DDFPe to safely extend the time window for tPA thrombolysis to 9 h after stroke. Dated: 2015