A Phase Ib/II clinical trial of DDFPe as a radiosensitizer in glioblastoma
Although small, this trial shows that DDFPe used as a radiosensitizer appears to be safe and may provide some survival benefit.
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- Apr 16, 2016
TOLD MRI validation of reversal of tumor hypoxia in glioblastoma with a novel oxygen therapeutic
MRI scans indicated that oxygen breathing with DDFPe administration improved tumor oxygenation.
- Mar 1, 2016
Reversal of Tumor hypoxia following intravenous delivery of DDFPe
DDFPe results in a significant increase in intra-tumoral oxygen tension for up to 45 minutes in our pancreatic xenograft model in mice.
- Nov 10, 2015
Dynamic Oxygenation Measurements Using a Phosphorescent Coating Window Chamber Model
Intravenous injection of DDFPe in mice with tumors increases tumor oxygen levels.
- Feb 1, 2015
Radiosensitization of Hs-766T Pancreatic Tumor Xenografts in Mice Dosed with DDFPe
DDFPe administration in mice with pancreatic tumor xenografts resulted in increased tumor oxygen tension lasting up to two hours.
- Jul 1, 2002
Radiosensitization of hypoxic tumor cells by DDFPe
DDFP plus carbogen appears to completely reverse the hypoxic cell radioresistance in this rat tumor model.