Treatment of Swine Closed Head Injury with Perfluorocarbon
NanO2 may assist in mitigating secondary cellular brain damage after traumatic brain injury.
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- Feb 12, 2020
Welcoming the New Kid on the Block; A Phase IIb Study of DDFPe in Large Vessel Strokes
The design for an efficient Phase IIb clinical trial in stroke to test DDFPe in patients with Large Vessel Occlusions.
- Nov 11, 2019
A Phase Ib/II clinical trial of DDFPe as a radiosensitizer in glioblastoma
Although small, this trial shows that DDFPe used as a radiosensitizer appears to be safe and may provide some survival benefit.
- Aug 28, 2019
Dodecafluoropentane Emulsion in Acute Ischemic Stroke: A Phase Ib/II Trial
This randomized, placebo-controlled, double-blind, dose-escalation clinical trial in acute ischemic stroke patients was designed to...
- Mar 1, 2019
Imaging assessment of cardioprotection mediated by DDFPe administered during myocardial infarction
DDFPe treatment in rats with myocardial infarction was associated by significantly reduced ischemia-reperfusion injury.
- Feb 28, 2019
NuvOx Pharma’s NanO2 Shows Positive Results in Phase Ib/II Stroke Trial
Positive results of NuvOx Pharma’s NanO2 (DDFPe) in the treatment of stroke have been published at the International Stroke Conference. A...
- Jan 29, 2019
In vitro model to compare the oxygen offloading behaviour of dodecafluoropentane emulsion (DDFPe)
DDFPe efficiently offloads oxygen to hypoxic environments. Link to publication
- Nov 8, 2017
DDFPe as a Resuscitation Fluid for Hemorrhagic Shock and Traumatic Brain Injury: A Review
Animal studies, for both hemorrhagic shock and TBI, show promising effects of DDFPe as a resuscitation fluid.
- Jul 11, 2017
DDFPe reduced secondary brain injury in a Swine Model of Traumatic Brain Injury
In this swine model of TBI, administration of DDFPe resulted in lower injury scores for
spongiosis and ischemic neurons.
- Aug 8, 2016
Dodecafluoropentane Improves Neurological Function Following Anterior Ischemic Stroke
DDFPe reduces infarct volume and neurological function following anterior ischemic stroke.
- Apr 16, 2016
TOLD MRI validation of reversal of tumor hypoxia in glioblastoma with a novel oxygen therapeutic
MRI scans indicated that oxygen breathing with DDFPe administration improved tumor oxygenation.
- Mar 1, 2016
DDFPe increased cerebral oxygen tension after traumatic brain injury in rats.
DDFPe increased brain tissue oxygen tension following TBI in rats and should be evaluated further as a possible treatment for TBI.
- Mar 1, 2016
Reversal of Tumor hypoxia following intravenous delivery of DDFPe
DDFPe results in a significant increase in intra-tumoral oxygen tension for up to 45 minutes in our pancreatic xenograft model in mice.
- Nov 10, 2015
Dynamic Oxygenation Measurements Using a Phosphorescent Coating Window Chamber Model
Intravenous injection of DDFPe in mice with tumors increases tumor oxygen levels.
- Oct 31, 2015
DDFPe Extends Window for tPA Therapy in a Rabbit Stroke Model
DDFPe significantly extends the time window for tPA therapy.
- Feb 16, 2015
DDFPe delays and reduces MRI markers of infarction in a rat stroke model
DDFPe delays and reduces MRI markers of stroke in the early hours following vascular occlusion in a rat stroke model.
- Feb 9, 2015
Multiple Applications of DDFPe Prevents Death in a Rabbit Stroke Model
Increasing the number of DDFPe applications was significant in reducing the incidence of premature death.
- Feb 1, 2015
A preliminary PET evaluation of DDFPe effects on rabbit brain hypoxia in stroke
DDFPe alleviates hypoxia in areas of ischemia.
- Feb 1, 2015
Radiosensitization of Hs-766T Pancreatic Tumor Xenografts in Mice Dosed with DDFPe
DDFPe administration in mice with pancreatic tumor xenografts resulted in increased tumor oxygen tension lasting up to two hours.
- Dec 30, 2014
DDFPe Decreases Stroke Size and Improves Neurological Scores in a Rat Stroke Model
DDFPe treatment provides significant neuroprotection when assessed six hours post stroke.
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