Effects of DDFPe on cerebral microvasculature in the healthy rat.
asoconstriction in cerebral pial arterioles of healthy rats.
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- Oct 16, 2014
DDFPe Elicits Cardiac Protection Against Myocardial Infarction
Rats given DDFPe see a 72% reduction in myocardial infarct volume at 24 hours.
- Oct 31, 2013
Progress in Dodecafluoropentane Emulsion as a Neuroprotective Agent in a Rabbit Stroke Model
Intravenous DDFPe decreases ischemic stroke infarct volumes. Rapid development is warranted.
- Nov 12, 2011
Dodecafluoropentane Emulsion Decreases Infarct Volume in a Rabbit Ischemic Stroke Model
Intravenous DDFPe in an animal model decreases infarct volumes and protects brain tissue from ischemia justifying further investigation.
- Apr 30, 2010
Hypoxia due to shunts in pig lung treated with DDFPe
19 pigs with depressed arterial oxygen tensions had DDFPe administered. DDFPe increased arterial, venous, and muscle oxygen tensions.
- Mar 1, 2010
Basic mechanisms of gas transport and past research using perfluorocarbons
DDFPe improves the efficiency of oxygen exchange between blood and tissue. Link to publication
- Jul 1, 2009
Development of a Minimal-Bulk Oxygen Delivery Product to Enhance Survival during Hemorrhagic Shock
US Army experiments concluding that DDFPe is a better resuscitation fluid then Hextend.
- Jun 22, 2009
In Vitro Comparison of Dodecafluoropentane (DDFPe), Perfluorodecalin, and Perfluoroctylbromide
DDFPe absorbs more oxygen than other perfluorocarbon emulsions in-vitro.
- Dec 31, 2006
DDFPe protects against fatal anemia in rats.
DDFPe treated rats see 100% survival at hemoglobin levels lower than what is fatal in 100% of controls.
- Dec 7, 2004
Longterm survival of potentially lethal hemorrhagic shock after treatment with DDFPe
Pigs given 50% blood loss see 20% survival in controls (n=5) and 100% survival in those given DDFPe (n=5).
- Mar 4, 2003
Hemorrhagic shock in Air Breathing Pigs Treated with DDFPe
Air breathing pigs are given severe bleeding and either placebo or DDFPe. 0% of placebo animals survive. 100% of DDFPe animals survive.
- Jul 1, 2002
Radiosensitization of hypoxic tumor cells by DDFPe
DDFP plus carbogen appears to completely reverse the hypoxic cell radioresistance in this rat tumor model.
- Sep 10, 2001
DDFPe Provides Vital Oxygenation In Hemoglobin Depleted Pigs during Air Breathing
US Army Studies concluding that DDFPe holds promise in combat casualty care, even when oxygen is not readily available.
- Apr 27, 2001
Human pharmacokinetics of a DDFPe with gas chromatography
In this human PK study, DDFPe was given to 24 volunteers. DDFPe blood concentration decreases quickly. The drug is exhaled unmetabolized.
- Nov 11, 2000
DDFPe for treatment of hypoxemia due to an experimental pulmonary shunt
Pigs had airways blocked and were given 100% O2 to breathe. DDFPe infusions increase arterial oxygen tensions within minutes.
- Oct 3, 2000
Method for enhancing transport of gasses to tissues
DDFPe increases arterial oxygen tension and muscle oxygen tension in pigs with pulmonary shunt.
- Nov 12, 1999
DDFPe used for successful treatment of shunts in the lung
In pigs that haid airflow in the lungs blocked by steel beads, administering DDFPe increased blood and muscle oxygen levels.
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