A Phase Ib/II clinical trial of DDFPe as a radiosensitizer in glioblastomaAlthough small, this trial shows that DDFPe used as a radiosensitizer appears to be safe and may provide some survival benefit.
TOLD MRI validation of reversal of tumor hypoxia in glioblastoma with a novel oxygen therapeuticMRI scans indicated that oxygen breathing with DDFPe administration improved tumor oxygenation.
Reversal of Tumor hypoxia following intravenous delivery of DDFPeDDFPe results in a significant increase in intra-tumoral oxygen tension for up to 45 minutes in our pancreatic xenograft model in mice.
Dynamic Oxygenation Measurements Using a Phosphorescent Coating Window Chamber ModelIntravenous injection of DDFPe in mice with tumors increases tumor oxygen levels.