Although small, this trial shows that DDFPe used as a radiosensitizer appears to be safe and may provide some survival benefit.

MRI scans indicated that oxygen breathing with DDFPe administration improved tumor oxygenation.

DDFPe results in a significant increase in intra-tumoral oxygen tension for up to 45 minutes in our pancreatic xenograft model in mice.

Intravenous injection of DDFPe in mice with tumors increases tumor oxygen levels.

DDFPe administration in mice with pancreatic tumor xenografts resulted in increased tumor oxygen tension lasting up to two hours.

DDFP plus carbogen appears to completely reverse the hypoxic cell radioresistance in this rat tumor model.