An experiment testing the frequency of dosing in a standard pMCAO and non-standard permanent posterior cerebral circulation occlusion model in rabbits. There was no significant difference between dosing every 30 mins vs. every 60 minutes. In the standard anterior strokes, DDFPe improves infarct volume and neurological function, but not in the more severe nonstandard strokes. It is hypothesized that the lack of difference in the non-standard posterior model was due to a higher vulnerability of the brainstem to ischemia or a lack of collateral blood vessels from which DDFPe supplies oxygen to the ischemic region.
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