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Pipeline

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NanO  has completed Phase Ib/II clinical trials in acute ischemic stroke and glioblastoma (see publications section).

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Phase III

Sickle Cell Crisis

Pre-clinical 

Phase Ib/IIa

Phase IIb

Medical Indication

Stroke

Oncology / GBM

AHRF / COVID-19

TBI

Myocardial Infarction

Hemorrhagic Shock

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A New Paradigm in Oxygen Delivery

NuvOx’s discovery of NanO       as the world’s most effective oxygen therapeutic derives from Dr. Unger’s pioneering work in microbubbles. Dr. Unger’s first company, ImaRx Pharmaceutical, developed the world’s #1 selling microbubble product, Definity®, as an ultrasound contrast agent.

 

The active substance in microbubbles is a class of compounds called perfluorocarbons. Several generations of perfluorocarbon emulsions were developed as blood substitutes. The early generations used perfluorocarbons with high boiling points (greater than 142   C). Dr. Unger recognized that perfluorocarbons with lower boiling points, as used in microbubbles, would be more efficient oxygen carriers.

 

Dodecafluoropentane emulsion (DDFPe) was originally developed as an ultrasound contrast agent that never launched. Dodecafluoropentane boils at 29  C, less than body temperature, but is stable to storage as a liquid nanoemulsion. Recognizing the potential of DDFPe to deliver far more oxygen than previous perfluorocarbons, Dr. Unger licensed the patents and obtained ownership of the regulatory documents for DDFPe and launched the program to develop NanO  .

 

NanO  improves the flow of oxygen between blood and tissue. Multiple studies have confirmed the potential of NanO  showing efficacy at less than 1% the dose of the prior perfluorocarbons. NanO  represents a new paradigm in oxygen delivery.

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Consistent Results

NanO 's unique mechanism of action allows it to improve the flow of oxygen from lungs to blood and from blood to tissue. Over 30 animal studies have shown therapeutic effect in seven different indications where hypoxia is life threatening.

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