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Dodecafluoropentane Emulsion in Acute Ischemic Stroke: A Phase Ib/II Trial

This randomized, placebo-controlled, double-blind, dose-escalation clinical trial in acute ischemic stroke patients was designed to demonstrate maximum tolerated dose, characterize adverse events (AEs), and explore clinical outcomes when intravenous DDFPe was used as neuroprotection. Intravenous DDFPe appears to be safe at all doses tested. Clinical improvements in NIHSS score and mRS were significant but compromised by small sample size.


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